6th Sem Biopharmaceutics And Pharmacokinetics Syllabus

 UNIT-I  (View PDF)

Introduction Biopharmaceutics to Absorption; Mechanisms of drug absorption through GIT, factors influencing drug absorption though GIT, absorption of drug from Non per oral extra-vascular routes, Distribution Tissue permeability of drugs, binding of drugs, apparent, volume of drug distribution, plasma and tissue protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs

UNIT- II  (View PDF)

Elimination: Drug metabolism and basic understanding metabolic pathways renal

excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non renal

routes of drug excretion of drugs

Bioavailability and Bioequivalence: Definition and Objectives of bioavailability, absolute and relative bioavailability, measurement of bioavailability, in-vitro drug

dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to

enhance the dissolution rates and bioavailability of poorly soluble drugs.

UNIT- III  (View PDF)

Pharmacokinetics: Definition and introduction to Pharmacokinetics, Compartment

models, Non compartment models, physiological models, One compartment open

model. (a). Intravenous Injection (Bolus) (b). Intravenous infusion and (c) Extra

vascular administrations. Pharmacokinetics parameters - KE ,t1/2,Vd,AUC,Ka, Clt and

CLR- definitions methods of eliminations, understanding of their significance and

application

UNIT- IV  (View PDF)

Multicompartment models: Two compartment open model. IV bolus

Kinetics of multiple dosing, steady state drug levels, calculation of loading and

mainetnance doses and their significance in clinical settins.

UNIT- V  (View PDF)

Nonlinear Pharmacokinetics: a. Introduction, b. Factors causing Non-linearity. c. Michaelis-menton method of estimating parameters, Explanation with example of

drugs.