3rd Sem Pharmaceutical Organic Chemistry-2 Syllabus

  UNIT I  (View PDF)

Benzene and its derivatives

A. Analytical, synthetic and other evidences in the derivation of structure

of benzene, Orbital picture, resonance in benzene, aromatic

characters, Huckel’s rule

B. Reactions of benzene - nitration, sulphonation, halogenation-

reactivity, Friedelcrafts alkylation- reactivity, limitations,

Friedelcrafts acylation.

C. Substituents, effect of substituents on reactivity and orientation of

mono substituted benzene compounds towards electrophilic substitution reaction

D. Structure and uses of DDT, Saccharin, BHC and Chloramine

UNIT II  (View PDF)

Phenols - Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols.

Aromatic Amines - Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts.

Aromatic Acids –Acidity, effect of substituents on acidity and important reactions of benzoic acid. 

UNIT III  (View PDF)

Fats and Oils

a. Fatty acids – reactions.

b. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.

c. Analytical constants – Acid value, Saponification value, Ester value,

Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and principle involved in their determination.

UNIT IV   (View PDF)

Polynuclear hydrocarbons:

a. Synthesis, reactions

b. Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives

UNIT V  (View PDF)

Cyclo alkanes

Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only